Ghrelin and leptin are two hormones that have been recognized to have a major influence on energy balance and weight. 

Today, we are going to focus on ghrelin, and you can read about the King of Hormones… Leptin… in my next post.

The discovery of ghrelin in 1999 is a major breakthrough in understanding the critical biologic function of regulating energy homeostasis. Future research will certainly be exciting for the possibility of developing new avenues to energy balance and diseases of impaired growth.


Ghrelin is a fast-acting hormone secreted by the stomach that makes you hungry. It also plays a significant role in how quickly your hunger starts tugging at you again. Ghrelin also has an effect on the gastrointestinal tract, immune cell activation and inflammation.
The ghrelin hormone not only stimulates the brain giving rise to an increase in appetite, but also favours the accumulation of lipids in visceral fatty tissue, located in the abdominal zone and considered to be the most harmful. This is the conclusion of research undertaken at Metabolic Research Laboratory of the University Hospital of Navarra, published recently in the International Journal of Obesity.
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